米国の医師資格試験でChatGPTの答えが不正解だった例。
以下はUnited States Medical Licensing Exam (USMLE) のウェブサイトに掲載されている医師資格試験の例題の1つで答えは(B) Imiquimod。
A 31-year-old man with a 5-year history of HIV infection comes to the office because of anal pain, particularly on defecation, for the past 4 months. He says he has seen spots of blood on the toilet tissue but has not had any other noticeable bleeding. He reports no change in bowel habits and has not had recent fever, chills, or rectal drainage. He says he and his partner engage in anal-receptive intercourse. His most recent CD4+ T-lymphocyte count 2 months ago was 350/mm3 ; HIV viral load at that time was undetectable. He currently is being treated with antiretroviral therapy. He has had no opportunistic infections. Medical history is also significant for syphilis and genital herpes treated with penicillin and acyclovir, respectively. He does not smoke cigarettes or drink alcoholic beverages. Vital signs are normal. Physical examination shows small bilateral inguinal lymph nodes, but respiratory, cardiac, and abdominal examinations disclose no abnormalities. There are several tender fleshy lesions around the perianal area. Rectal examination produces tenderness, but there is no rectal discharge. Test of the stool for occult blood is trace positive. Which of the following is the most appropriate pharmacotherapy at this time?
(A) Acyclovir
(B) Imiquimod
(C) Levofloxacin
(D) Metronidazole
(E) Penicillin
しかしChatGPTは以下の理由により(D) Metronidazoleを正解とした。
The patient’s symptoms of anal pain, particularly during defecation, along with the presence of tender fleshy lesions around the perianal area and a trace positive test for occult blood in the stool, suggest a possible diagnosis of anal gonorrhea or rectal chlamydia. These infections are common in men who engage in anal-receptive intercourse and can cause pain and inflammation in the rectal area. Metronidazole is an effective treatment for these infections. Acyclovir can be used to treat genital herpes, but is not effective for gonorrhea or chlamydia. Imiquimod is used to treat external genital warts and is not indicated for anal infections. Levofloxacin and penicillin are not effective for treating gonorrhea or chlamydia. The patient’s HIV status should also be taken into consideration when choosing the most appropriate treatment.
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